This podcast discusses behavioral disorders and a ketogenic therapeutic intervention.
Listennotes uses voice-to-text technology to create a full transcript. You can find it located below each podcast. While it is rough, readers may find it useful.
- 1:17 Welcome, Christopher Palmer, MD
Ketogenic diet and addiction
- 3:20 Nora Volkow, MD. Director National Institute on Drug Abuse. Research implies some foods activate the same reward pathways as addictive substances.
- 6:02 Alcohol and insulin resistance
- 7:02 Study of ketogenic diet and alcoholism
- 13:25 Alcohol converts to acetone and fuels the brain. (The big three ketone bodies are beta-hydroxybutyrate, acetoacetate, and acetone.)
Chris and his father’s success stories
- 16:55 How Chris Palmer discovered low-carb dieting and his own metabolic dysfunction
- 23:45 Chris’s father’s story of diabetes and recovery
- 39:11 Chris’s personal diet and exercise plan
Part 2: Episode 64 – Keto Naturopath by Karl Goldcamp interviews Chris Palmer
- 8:05 Karl – Hard to encourage exercise to the non-athletic
- 8:42 Chris – Growing up with poor diet and no exercise
On a ketogenic diet people feel more energetic and want to start exercising
- 10:33 Mental and emotional changes with ketogenic diet
Metabolic – mental connection
- 13:36 Mental disorders
- 14:35 Stigma of mental illness
- 15:49 Mental disorders as metabolic disorders
- 16:36 Diabetes and insulin resistance in mental disorders
- 16:55 At onset of mental illness patient’s weight is normal. But their insulin resistance is already measurable.
- 19:39 bidirectional relationship between mental and metabolic disorders
Ketogenic diet as a therapeutic intervention
- 23:14 Ketogenic diet can stop seizures
- 24:37 Epilepsy treatments are commonly used in psychiatry
- 25:22 Metabolic defects in mental disorders
- 28:15 More research needed
- 29:09 Mental disorders are of unknown etiology
- 30:00 Off-label treatments
- 32:24 My hope is to better understand this metabolic mental overlap
- 33:29 Metabolic interventions don’t work for everyone. I wish they did. I’m using them to help those with serious, treatment-resistant illnesses.
- 33:46 New schizophrenia research by Chris Palmer, MD
- 35:46 Dream of a residential treatment program
- 39:02 Hopeful that this is a game-changing way of thinking about and addressing these disorders
Like-minded researchers and clinicians around the world
- 16:41 Others currently investigating the ketogenic diet for mental illness.
- 18:45 Many clinicians unwilling to use the ketogenic diet with the most serious. disorders. For example, bipolar, schizophrenia and chronic-disabling depression. Using the medical-ketogenic diet as a treatment requires a multi-faceted approach.
- 20:40 I desperately want to improve the lives of psychiatric patients
- 21:40 I want to motivate other mental health clinicians to learn about the ketogenic diet
- 22:40 It is going to take a movement to spur change
Mechanisms of Action
- 25:16 Medical practitioners require a mechanism of action
- 25:57 History of ketogenic diet
- 25:57 Better understood than any other dietary intervention
- 27:49 Neurologist have been studying this since the 1970s
- 28:23 Probably 20 different mechanisms of action have already been elucidated. They suggest why the ketogenic diet can stop seizures .
- 29:19 Increasing Gaba, a primary inhibitory neurotransmitter in the brain.
- 31:24 This diet also increases activity of adenosine, which is a has a similar action on the brain
- 33:10 The ketogenic diet helps repair mitochondria. This helps it increase production of new mitochondria.
- 34:19 The ketogenic diet stimulates some pathways that result in anti-aging.
Fasting and the origin of the ketogenic diet
- 37:39 Fasting and the ketogenic diet both significantly change metabolism.
- 38:15 Fasting has a long history
- 40:16 The epilepsy world put it to some rigorous tests and they found it actually works for a real brain disorder, and you know they have been using it for a hundred years.
- 41:08 Does not stop seizures 100%
- 42:08 Some are skeptical of it because it doesn’t work immediately.
- 44:19 Lab monitoring
- 46:39 Cortisol.